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  • Title: Pathogenicity island-dependent effects of Helicobacter pylori on intracellular signal transduction in epithelial cells.
    Author: Naumann M.
    Journal: Int J Med Microbiol; 2005 Sep; 295(5):335-41. PubMed ID: 16173500.
    Abstract:
    Helicobacter pylori is a microbial pathogen that colonises the stomach of more than half of the world's human population. H. pylori infection can induce chronic gastritis, peptic ulceration and more rarely, gastric adenocarcinoma. A prominent feature of H. pylori is the presence of a pathogenicity island (PAI) which encodes a type IV secretion system (T4SS). This review focuses on the processes of how H. pylori induces PAI-dependent epithelial cell signalling that might be of importance in gastric inflammation and the pathogenesis of neoplasia.
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