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  • Title: (+)-Phorboxazole A synthetic studies. A highly convergent, second generation total synthesis of (+)-phorboxazole A.
    Author: Smith AB, Razler TM, Ciavarri JP, Hirose T, Ishikawa T.
    Journal: Org Lett; 2005 Sep 29; 7(20):4399-402. PubMed ID: 16178543.
    Abstract:
    [structure: see text] A second generation total synthesis of the potent antitumor agent (+)-phorboxazole A (1) has been achieved. The cornerstone of this approach comprises a more convergent strategy, involving late-stage Stille union of a fully elaborated C(1-28) macrocycle with a C(29-46) side chain. The second generation synthesis entails the longest linear sequence of 24 steps, with an overall yield of 4.2%.
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