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  • Title: One-pot construction of pyrazoles and isoxazoles with palladium-catalyzed four-component coupling.
    Author: Mohamed Ahmed MS, Kobayashi K, Mori A.
    Journal: Org Lett; 2005 Sep 29; 7(20):4487-9. PubMed ID: 16178565.
    Abstract:
    [reaction: see text] Four-component coupling of a terminal alkyne, hydrazine (hydroxylamine), carbon monoxide, and an aryl iodide furnishes pyrazole or isoxazole derivatives in the presence of a palladium catalyst. The reaction proceeds at room temperature and an ambient pressure of carbon monoxide in an aqueous solvent system.
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