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  • Title: Mutational analysis of the BRAF gene in human congenital and dysplastic melanocytic naevi.
    Author: Papp T, Schipper H, Kumar K, Schiffmann D, Zimmermann R.
    Journal: Melanoma Res; 2005 Oct; 15(5):401-7. PubMed ID: 16179867.
    Abstract:
    Eighteen congenital melanocytic naevi (CMN) from 17 patients and 18 dysplastic melanocytic naevi (DMN) from 18 patients were screened for mutations in the BRAF oncogene (present study) and the N-ras oncogene (in the course of two foregoing studies) by single-strand conformational polymorphism (SSCP)/sequencing analysis. BRAF mutations were demonstrated in both types of lesion. As a whole, 17 of 18 CMN (94.4%) and five of 18 DMN (27.7%) harboured either BRAF or N-ras mutations. As the BRAF oncogene is frequently found to be mutated in human cutaneous melanomas, it may constitute a risk factor for melanoma formation within CMN and DMN.
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