These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Cytotoxic sesquiterpene lactones from Vernonia pachyclada from the Madagascar rainforest.
    Author: Williams RB, Norris A, Slebodnick C, Merola J, Miller JS, Andriantsiferana R, Rasamison VE, Kingston DG.
    Journal: J Nat Prod; 2005 Sep; 68(9):1371-4. PubMed ID: 16180816.
    Abstract:
    Bioassay-guided fractionation of the cytotoxic leaf extract of Vernonia pachyclada Baker led to the isolation of three new sesquiterpene lactones, designated glaucolides K-M (1-3). The structures of the new compounds were determined using 1D and 2D NMR spectroscopy, and the structure and stereochemistry of 1 were confirmed by single-crystal X-ray diffraction. Compound 3 showed moderate activity in the A2780 human ovarian cancer cell line, with an IC50 of 3.3 microM.
    [Abstract] [Full Text] [Related] [New Search]