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  • Title: Chronic estrogen treatment modifies insulin-induced insulin resistance and hypertension in ovariectomized rats.
    Author: Song D, Arikawa E, Galipeau DM, Yeh JN, Battell ML, Yuen VG, McNeill JH.
    Journal: Am J Hypertens; 2005 Sep; 18(9 Pt 1):1189-94. PubMed ID: 16182108.
    Abstract:
    BACKGROUND: Gender differences have been found in the development of hypertension. The role of estrogen in the association between hyperinsulinemia/insulin resistance and hypertension was investigated in an insulin-induced, insulin-resistant, and hypertensive model. METHODS: Ovariectomized or sham operated female Wistar rats were chronically treated with insulin and/or estrogen via subcutaneous implants (insulin, 2 U/day; 17beta-estradiol 0.5 mg/pellet, 60-day release). Systolic blood pressure was monitored at weeks 0, 3, and 6. At week 7, an oral glucose tolerance test was performed. RESULTS: Ovariectomy resulted in the development of insulin resistance and blood pressure elevation in chronically insulin-treated female rats. Chronic estrogen treatment prevented the elevation in blood pressure and the development of insulin resistance. CONCLUSION: The results indicate that chronic estrogen treatment modifies the insulin-induced hypertension by increasing insulin sensitivity in ovariectomized rats.
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