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  • Title: Improved liver function and decreased hepatitis C viral load after tacrolimus was replaced by cyclosporine.
    Author: Lorho R, Turlin B, de Lajarte-Thirouard AS, Camus C, Lakehal M, Compagnon P, Meunier B, Boudjema K, Messner M.
    Journal: Transplant Proc; 2005; 37(6):2871-2. PubMed ID: 16182838.
    Abstract:
    Potential antiviral properties of cyclosporine against hepatitis C virus have been highlighted in several publications. Therefore, we investigated the effect of a switch from tacrolimus to cyclosporine in a liver transplant recipient with recurrent hepatitis C who did not respond to antiviral therapy. The patient received a liver transplant for hepatitis C cirrhosis. Initial immunosuppressive treatment was based on tacrolimus. Because of viral activity, a combined therapy was initiated 20 months later including interferon and ribavirine. Then, due to a lack of virological and biochemical response, tacrolimus was replaced by cyclosporine (Neoral), while maintaining the same antiviral therapy. Decreases in the viral load and transaminases levels were observed.
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