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  • Title: Synthesis and antimicrobial activity of 5-hydroxymethyl- 8-methyl-2-(N-arylimino)-pyrano[2,3-c]pyridine-3-(N-aryl)-carboxamides.
    Author: Zhuravel' IO, Kovalenko SM, Ivachtchenko AV, Balakin KV, Kazmirchuk VV.
    Journal: Bioorg Med Chem Lett; 2005 Dec 15; 15(24):5483-7. PubMed ID: 16183276.
    Abstract:
    Several novel 2-imino-5-hydroxymethyl-8-methyl-2H-pyrano[2,3-c]pyridine-3-(N-aryl) carboxamides were prepared by reaction of pyridoxal hydrochloride with various N-arylcyanoacetamides. Reaction of these compounds with aromatic amines furnished a wide series of 2-(N-R-phenyl) imino-5-hydroxymethyl-8-methyl-2H-pyrano[2,3-c]pyridine-3-carboxamides. Antibacterial and antifungal activities of the synthesized compounds were studied. Most of the obtained compounds demonstrated significant activity against bacterial or fungal strains (MIC in the range of 12.5-25microg/mL), displaying comparable or even better efficacy than the standard drugs.
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