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  • Title: Synthesis of chromenochalcones and evaluation of their in vitro antileishmanial activity.
    Author: Narender T, Khaliq T, Shweta, Nishi, Goyal N, Gupta S.
    Journal: Bioorg Med Chem; 2005 Dec 01; 13(23):6543-50. PubMed ID: 16185885.
    Abstract:
    A large number of novel chromenochalcones were synthesized by pyridine-catalysed chromenylation of mono-chelated meta-dihydric acetophenones with the monoterpene, citral dimethyl acetal and subsequent Claisen-Schmidt condensation of the resultant acylchromenes with appropriate aromatic aldehydes. These chromenochalcones 1-19 were screened against in vitro extracellular promastigotes and intracellular amastigotes of Leishmania donovani. The most potent compound in this series was compound 9 with a pyridine ring-A, which showed 99% inhibition of promastigotes at 10 microg/ml, 82% at 0.25 microg/ml and 96% at 10 microg/ml concentration against amastigotes.
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