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  • Title: Chorea induced by non-ketotic hyperglycaemia: a case report.
    Author: Branca D, Gervasio O, Le Piane E, Russo C, Aguglia U.
    Journal: Neurol Sci; 2005 Oct; 26(4):275-7. PubMed ID: 16193255.
    Abstract:
    We describe an 81-year-old woman presenting with sudden onset of generalised chorea. She was unaware of suffering from diabetes. Laboratory screening revealed non-ketotic hyperglycaemia. Brain magnetic resonance imaging (MRI) failed to show basal ganglia abnormalities. Monotherapy with subcutaneous regular insulin induced a progressive normalisation of glycaemia as well as a parallel improvement of the abnormal involuntary movement scale on a nine-day sequential observation. This correlation strongly supports the hypothesis that non-ketotic hyperglycaemia itself might play a major pathogenetic role in chorea associated with non-ketotic hyperglycaemia. Diabetes mellitus should be suspected in patients who develop sudden onset of chorea even in the absence of putaminal abnormalities on MRI.
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