These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Donepezil restores GH secretion in old rats without affecting the sleep/wake cycle.
    Author: Zizzari P, Bassant MH, Poindessous-Jazat F, Epelbaum J, Bluet-Pajot MT.
    Journal: Neurobiol Aging; 2006 May; 27(5):784.e1-784.e5. PubMed ID: 16199109.
    Abstract:
    A chronic treatment with a cholinesterase inhibitor, donepezil (0.085 mg/kg/h for 30 days) increases significantly the number and amplitude of growth hormone (GH) pulses in 3- and 24-month-old rats without modifying nadir GH values. This treatment does not reduce age-related alterations in sleep/wake cycle but it increases immobility-related high-voltage spindles (HVS) in old animals. These data suggest that cholinergic mechanisms involved in age-related alterations in GH and sleep regulation are different.
    [Abstract] [Full Text] [Related] [New Search]