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  • Title: Improved catalytic activity of homochiral dimeric cobalt-salen complex in hydrolytic kinetic resolution of terminal racemic epoxides.
    Author: Kureshy RI, Singh S, Khan NU, Abdi SH, Ahmad I, Bhatt A, Jasra RV.
    Journal: Chirality; 2005 Nov; 17(9):590-4. PubMed ID: 16200537.
    Abstract:
    Enantiomerically pure epoxides (99%, ee) and diols (98%, ee) from racemic epichlorohydrin, 1,2-epoxypropane, 1,2-epoxyhexane, 1,2-epoxyoctane, and 1,2-epoxydodecane were obtained in 2-12 h by hydrolytic kinetic resolution (HKR) using the recyclable dimeric homochiral Co(III)-salen complex 1' (0.2 mol %) derived from 5,5-(2',2'-dimethylpropane)-di-[(R,R)-{N-(3-tert-butylsalicylidine)-N'-(3',5'-di-tert-butylsalicylidine)}-1,2-cyclohexanediamine] with cobalt(II) acetate. Unlike its monomeric version, the catalyst could be recycled several times without loss in performance. The use of BF(4) as counter ion in HKR reactions was also investigated.
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