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  • Title: Riboflavin operon of Bacillus subtilis: unusual symmetric arrangement of the regulatory region.
    Author: Kil YV, Mironov VN, Gorishin IYu, Kreneva RA, Perumov DA.
    Journal: Mol Gen Genet; 1992 Jun; 233(3):483-6. PubMed ID: 1620102.
    Abstract:
    Seventeen cis-dominant mutations leading to riboflavin overproduction in Bacillus subtilis were localized to the region between nucleotides +37 and +159 relative to the transcription initiation site of the riboflavin operon. This region displays an unusual structure for regulatory sequences. The main part of it represents clusters of A/T and G/C-rich sequences that symmetrically blank a short inverted repeat.
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