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  • Title: [The 'memory lymphocyte immunostimulation assay' (MELISA) is useless for the detection of metal allergy].
    Author: Koene RA.
    Journal: Ned Tijdschr Geneeskd; 2005 Sep 17; 149(38):2090-2. PubMed ID: 16201597.
    Abstract:
    For the past several years, there has been an advertising campaign, especially focused on dentists, to promote the so-called 'memory lymphocyte immunostimulation assay' (MELISA) for the detection of metal allergy. A study of the sparse scientific literature reveals that, as a consequence of the high number of false-positive results, this test is of no use for the diagnosis of metal allergy. Moreover, the claims of the developers of the test that metal allergy plays a role in several immune-mediated diseases, metabolic diseases and neurological or mental disorders are not based on sound scientific evidence.
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