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  • Title: Tumor necrosis factor-alpha promoter polymorphism is associated with susceptibility to oral squamous cell carcinoma.
    Author: Liu CJ, Wong YK, Chang KW, Chang HC, Liu HF, Lee YJ.
    Journal: J Oral Pathol Med; 2005 Nov; 34(10):608-12. PubMed ID: 16202081.
    Abstract:
    BACKGROUND: Oral squamous cell carcinoma (OSCC) is one of the leading cancers in most Asian countries. Alterations of immune function have been detected in OSCC patients. The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) is a central mediator of the immune response involved in a wide range of immuno-inflammatory and infectious diseases. Polymorphism of the TNF-alpha gene has been intensively studied as a potential determinant of susceptibility to numerous cancers. METHODS: We genotyped 192 patients with OSCC and 146 healthy case controls by using polymerase chain reaction-double restriction fragment length polymorphism with amplification-created restriction sites to assess allelic determinants at the TNF-alpha polymorphic sites -308 and -238 in the promoter region. Genotype frequencies were evaluated with Fisher's test. RESULTS: The -308 TNFG (tumor necrosis factor G) allele genotype was higher in patients with OSCC (91.2% vs. 82.2%; P = 0.02) and TNFG/A was lower (8.3% vs. 11.8%; P = 0.02); the -238 TNFG/A allele genotype was lower in patient with OSCC (2.1% vs. 6.9%; P = 0.02). CONCLUSION: This is the first report that the TNF-alpha polymorphism is associated with the risk for OSCC in Taiwan.
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