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Title: [Study on classification and treatment of vulvovaginal candidiasis].
Author: Fan SR, Liu XP, Li JW, Xu AP, Liu M.
Journal: Zhonghua Fu Chan Ke Za Zhi; 2005 Aug; 40(8):532-5. PubMed ID: 16202291.
Abstract:
OBJECTIVE: To determine the clinical manifestations of vulvovaginal candidiasis (VVC) and to study the mycologic eradication rate of different miconazole treatment courses for VVC. METHODS: Three hundred cases of VVC were recruited. The Candidas were cultured. A prospective and randomized study was performed to compare the treatment effect of 3 day miconazole (400 mg/d), 6 day miconazole (400 mg/d), and 7 day miconazole (200 mg/d) for uncomplicated and complicated VVC. RESULTS: Among 300 cases of VVC, uncomplicated, complicated and recurrent VVC were 56.0%, 44.0% and 9.7% (29/300) respectively. C. albicans was isolated most frequently 90.3% (271/300), followed by C. glabrata (7.3%), C. tropicalis (1.3%), C. krusei (0.7%), and C. parapsilosis (0.3 %). Mycologic eradication rate of 3 day, 6 day and 7 day miconazole courses for uncomplicated VVC at day 14 was 96.0%, 93.5% and 98.0%, respectively (P > 0.05). Eradication rate of 3 day, 6 day and 7 day miconazole courses for complicated VVC at day 14 was 86.7%, 92.5%, and 86.4%, respectively (P > 0.05). Eradication rate of 3 day, 6 day and 7 day miconazole courses for uncomplicated VVC at day 35 was 93.8%, 95.3%, and 89.8%, respectively (P > 0.05). Eradication rate of 3 day, 6 day and 7 day miconazole courses for complicated VVC at day 35 was 89.7%, 97.3% and 86.8%, respectively (P > 0.05). CONCLUSION: Treatment of VVC should be individualized, and women with complicated VVC achieve superior mycologic eradication by a 6 day miconazole course.

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