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  • Title: Non-steroidal anti-inflammatory drug (NSAID)-induced colonic strictures and perforation: a case report.
    Author: Aloysius MM, Kaye PV, Lobo DN.
    Journal: Dig Liver Dis; 2006 Apr; 38(4):276-8. PubMed ID: 16203193.
    Abstract:
    Although non-steroidal anti-inflammatory drug-induced colopathy is well described, colonic perforations complicating non-steroidal anti-inflammatory drug intake are rare. We report a patient with rheumatoid arthritis who was on long-term diclofenac and presented with early colonic stricture formation and a caecal perforation, which to the best of our knowledge, has only been reported once before. It is important to suspect this diagnosis in patients on non-steroidal anti-inflammatory drug therapy who present with an acute abdomen.
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