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  • Title: Stereoselective synthesis of (2S,3S,4R,5S)-5-methylpyrrolidine-3,4-diol derivatives that are highly selective alpha-L-fucosidase inhibitors.
    Author: Moreno-Vargas AJ, Carmona AT, Mora F, Vogel P, Robina I.
    Journal: Chem Commun (Camb); 2005 Oct 21; (39):4949-51. PubMed ID: 16205810.
    Abstract:
    N-Phenylaminomethyl benzimidazolyl moieties attached at C-2 of (2S,3S,4R,5S)-5-methylpyrrolidine-3,4-diol increase the potency and selectivity of the inhibitory activity of these systems towards alpha-L-fucosidases.
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