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  • Title: Caffeine and psychiatric medication interactions: a review.
    Author: Broderick PJ, Benjamin AB, Dennis LW.
    Journal: J Okla State Med Assoc; 2005 Aug; 98(8):380-4. PubMed ID: 16206866.
    Abstract:
    Caffeine can cause or worsen psychiatric symptoms but also has the potential to interact with many psychiatric medications. This article provides a literature review regarding interactions between caffeine and psychiatric medications. Caffeine is metabolized by the CYP1A2 enzyme and also acts as a competitive inhibitor of this enzyme. Thus, caffeine can interact with a wide range of psychiatric medications, including antidepressant agents, antipsychotic agents, antimanic agents, antianxiety agents, and sedative agents. These interactions may lead to caffeine-related or medication-related side effects that may complicate psychiatric treatment. By recognizing this potential, along with educating the patient, and utilizing a tapering approach, prevention of caffeine interactions is achievable.
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