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  • Title: [Diagnosis and therapy of weakly-acid/non-acidic gastroesophageal reflux disease].
    Author: Meining A, Bajbouj M, Stein HJ, Schmid RM.
    Journal: Dtsch Med Wochenschr; 2005 Oct 07; 130(40):2266-9. PubMed ID: 16208602.
    Abstract:
    The therapy of gastroesophageal reflux disease (GERD) is uncomplicated in most cases. However, 20 % of GERD patients suffer from reflux-associated symptoms under therapy with proton pump inhibitors (PPI). The cause of this resistance to PPI-therapy remains unclear. Today, the most discussed theory is the presence of the non- or weakly acidic reflux. Objective measurements of the weakly/non-acidic reflux are available since the development of intraluminal impedance monitoring in combination with pH-monitoring. The therapy of weakly/non-acidic GERD is not well established, so far. In the course of clinical studies the therapeutic spectrum (i. e. modification of the medical therapy, endoscopic anti-reflux procedures or surgical therapy) has to be tested.
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