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  • Title: Application of a domino intramolecular enyne metathesis/cross metathesis reaction to the total synthesis of (+)-8-epi-xanthatin.
    Author: Kummer DA, Brenneman JB, Martin SF.
    Journal: Org Lett; 2005 Oct 13; 7(21):4621-3. PubMed ID: 16209494.
    Abstract:
    [reaction: see text] The first total synthesis of the novel sesquiterpene lactone (+)-8-epi-xanthatin (1) has been achieved starting from the commercially available ester 8. The synthesis features an asymmetric aldol reaction and palladium-catalyzed carbonylation/lactonization sequence leading to 4 and a domino ring-closing enyne metathesis/cross metathesis reaction to afford 1.
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