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  • Title: CuI/L-proline-catalyzed coupling reactions of aryl halides with activated methylene compounds.
    Author: Xie X, Cai G, Ma D.
    Journal: Org Lett; 2005 Oct 13; 7(21):4693-5. PubMed ID: 16209512.
    Abstract:
    [reaction: see text] The arylation of ethyl acetoacetate, ethyl benzoyl acetate, and diethyl malonate under the catalysis of CuI/L-proline in DMSO proceeds smoothly at 40-50 degrees C in the presence of Cs2CO3 to provide the 2-aryl-1,3-dicarbonyl compounds in good yields. Both aryl iodides and aryl bromides are compatible with these reaction conditions.
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