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  • Title: Pyrazolo[1,5-a]pyridines as p38 kinase inhibitors.
    Author: Stevens KL, Jung DK, Alberti MJ, Badiang JG, Peckham GE, Veal JM, Cheung M, Harris PA, Chamberlain SD, Peel MR.
    Journal: Org Lett; 2005 Oct 13; 7(21):4753-6. PubMed ID: 16209527.
    Abstract:
    [reaction: see text] A convergent synthesis of substituted pyrazolo[1,5-a]pyridines has been achieved either via a regioselective [3 + 2] cycloaddition of N-aminopyridines with alkynes or by thermal cyclization of disubstituted azirines. Subsequent palladium-catalyzed introduction of pyridines or de novo synthesis of pyrimidines affords inhibitors of p38 kinase.
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