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  • Title: [Role of exogenous fibrinogen in the processes of degranulation of thrombocytes stimulated with thrombin. Ultrastructural study using fibrinogen labeled with colloidal gold].
    Author: Belitser NV, Anishchuk MG, Veklich IuI, Smekhova TR, Pozdniakova TM, Gorkun OV, Chernyshenko TM, Moroz ED.
    Journal: Tsitol Genet; 1992; 26(1):3-8. PubMed ID: 1621283.
    Abstract:
    Using colloidal gold-conjugated fibrinogen (F-Au) it is shown that exogenous fibrinogen can participate in the platelet release reaction. In the absence of F-Au, internal secretory vacuoles readily formed in human platelets stimulated with thrombin, but extrusion of their content was delayed. Upon incubation with F-Au, endocytic channels induced by F-Au-receptor interactions, fused with internal vacuoles, thus establishing spatial communications of the latter with the outer medium.
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