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  • Title: Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors.
    Author: Zbinden KG, Obst-Sander U, Hilpert K, Kühne H, Banner DW, Böhm HJ, Stahl M, Ackermann J, Alig L, Weber L, Wessel HP, Riederer MA, Tschopp TB, Lavé T.
    Journal: Bioorg Med Chem Lett; 2005 Dec 01; 15(23):5344-52. PubMed ID: 16213138.
    Abstract:
    We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway.
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