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  • Title: Modular polyketide synthases: Investigating intermodular communication using 6 deoxyerythronolide B synthase module 2.
    Author: Moffet DA, Khosla C, Cane DE.
    Journal: Bioorg Med Chem Lett; 2006 Jan 01; 16(1):213-6. PubMed ID: 16213712.
    Abstract:
    A novel variant of 6-deoxyerythronolide B synthase (DEBS) module 2 was constructed to explore the balance between protein-protein-mediated intermodular channeling and intrinsic substrate specificity within DEBS. This construct, termed (N3)Mod2+TE, was co-incubated with a complementary, donor form of the same module, (N5)Mod2(C2), as well as with a mutant of (N5)Mod2(C2) with an inactive ketosynthase domain, in order to determine the extent of intermediate channeling versus substrate diffusion into the downstream module.
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