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  • Title: Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents.
    Author: Suresh Babu K, Hari Babu T, Srinivas PV, Hara Kishore K, Murthy US, Rao JM.
    Journal: Bioorg Med Chem Lett; 2006 Jan 01; 16(1):221-4. PubMed ID: 16213726.
    Abstract:
    The natural product, chrysin (5,7-dihydroxy flavone), obtained from Oroxylum indicum, exhibits numerous biological activities including anticancer, anti-inflammatory, and antiallergic activities. Three series of chrysin analogues were prepared, in which chrysin and heterocyclic moieties are separated by 3-carbon, 4-carbon, and 6-carbon spacers. All the derivatives were screened for antibacterial activity against a panel of susceptible and resistant Gram-positive and Gram-negative organisms. It was observed that most of the derivatives displayed significant activity as compared to their parent compound (chrysin).
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