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  • Title: Experimental and clinical experience of albumin coating of tympanostomy tubes.
    Author: Kinnari TJ, Jero J.
    Journal: Otolaryngol Head Neck Surg; 2005 Oct; 133(4):596-600. PubMed ID: 16213935.
    Abstract:
    OBJECTIVE: Otorrhea and tube occlusion are typical problems with tympanostomy tubes (TT). The purpose of this study was to test glue protein, fibronectin adhesion on albumin-coated and uncoated TT surfaces and to show the effect of this method on TT sequelae in vivo. STUDY DESIGN AND SETTINGS: Fibronectin binding on TT surface was tested in two in vitro experiments. Thereafter 170 patients were randomized in a prospective clinical trial to test the effect of the method in vivo. The extruded TTs that could be collected from ears of some study patients were imaged with scanning electron microscopy (SEM). RESULTS: Marked binding inhibition of fibronectin on albumin-coated TTs was found. Fewer tube sequelae were found in ears with albumin-coated TTs. SEM revealed thick crusts on uncoated tube surface. CONCLUSION: Albumin coating of TTs can reduce unwanted adhesion on the tube surface in vitro and tube occlusions in vivo. SIGNIFICANCE: TT sequelae can be reduced by surface coating with albumin.
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