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  • Title: Mannose-binding lectin gene polymorphism and its impact on human immunodeficiency virus 1 infection.
    Author: Vallinoto AC, Menezes-Costa MR, Alves AE, Machado LF, de Azevedo VN, Souza LL, Ishak Mde O, Ishak R.
    Journal: Mol Immunol; 2006 Mar; 43(9):1358-62. PubMed ID: 16214215.
    Abstract:
    Mannose-binding lectin (MBL) is a serum protein whose low concentration is associated with the occurrence of allele variants named MBL*B, MBL*C and MBL*D. The present study investigated the association between MBL gene polymorphism and the susceptibility to HIV-1 infection. The study of 145 HIV-1-infected subjects and 99 healthy controls showed the presence of alleles MBL*A, MBL*B and MBL*D, whose frequencies were 69%, 22% and 09% among patients and 71%, 13% and 16% among healthy controls, respectively. The presence of the variant MBL*B was associated with higher plasma viral load levels, suggesting the importance of the MBL gene polymorphism in the clinical evolution of HIV-1-infected patients.
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