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  • Title: [Association study of sleep apnea syndrome and polymorphisms in the serotonin transporter gene].
    Author: Yue WH, Liu PZ, Hao W, Zhang XH, Wang XP, Zhang JS, Zhou XH, Xie YB, Ni M.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2005 Oct; 22(5):533-6. PubMed ID: 16215942.
    Abstract:
    OBJECTIVE: To identify polymorphisms of the serotonin transporter(5-HTT) gene and to find out whether there was relationship between any such polymorphisms and sleep apnea syndrome (SAS). METHODS: For two polymorphisms of 5-HTT target DNA gene was amplified using polymerase chain reaction (PCR) and 6% non-denaturing polyacrylamide gels electrophoresis. The frequencies of the different forms of the genotypes and alleles of 5-HTT gene were analyzed in 104 patients with SAS and 150 healthy controls. RESULTS: The frequencies of the S or L alleles and the S/S, S/L or L/L genotypes in promoter region of 5-HTT gene in SAS group were not significantly different to those in healthy controls (P > 0.05). However, the frequencies of 10/10, 12/10 genotypes of 5-HTT-VNTR in SAS patients were significantly higher than those in healthy control subjects (P < 0.05). Moreover, the frequency of the allele 10 of 5-HTT-VNTR in SAS patients was significantly higher than that in healthy controls (P<0.01). CONCLUSION: The allele 10 of 5-HTT-VNTR might be a susceptible factor in the pathogenesis of SAS.
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