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  • Title: [Correlation between fibrinogen polymorphisms and the type of cerebral infarction].
    Author: Wang SJ, Yuan XD, Gao J, Pei HZ, Li HF.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2005 Oct; 22(5):572-4. PubMed ID: 16215953.
    Abstract:
    OBJECTIVE: To study the association of beta-fibrinogen(Fg) gene -148 C/T and 448 G/A polymorphisms, plasma Fg concentration, molecular reactivity and the type of cerebral infarction. METHODS: Gene polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism. The plasma Fg concentration and the molecular reactivity were also determined. RESULTS: The Fg concentration in MCI patients with T -148 allele was higher than that in PCI patients and controls. The MCI patients with A448 allele had higher Fg concentration, FMPV and FMPV/Amax when compared with controls, and had higher FMPV/Amax when compared with PCI patients. CONCLUSION: FgB beta -148 and 448 mutational genotypes have impact on Fg concentrationì and therefore increase the risk of MCI.
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