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  • Title: Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection.
    Author: Burchat A, Borhani DW, Calderwood DJ, Hirst GC, Li B, Stachlewitz RF.
    Journal: Bioorg Med Chem Lett; 2006 Jan 01; 16(1):118-22. PubMed ID: 16216497.
    Abstract:
    We describe the identification, SAR, and pharmacology of the src-family selective lck inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days.
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