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  • Title: Analysis of vascular endothelial growth factor (VEGF) functional variants in rheumatoid arthritis.
    Author: Rueda B, González-Gay MA, López-Nevot MA, García A, Fernández-Arquero M, Balsa A, Pablos JL, Pascual-Salcedo D, de la Concha EG, González-Escribano MF, Martín J.
    Journal: Hum Immunol; 2005 Aug; 66(8):864-8. PubMed ID: 16216669.
    Abstract:
    The vascular endothelial growth factor (VEGF) is one of the most important pro-angiogenic mediators related to inflammation-associated synovial angiogenesis. The aim of this study was to asses the role of -1154 G-->A (rs1570360) and -634 G-->C (rs2010963) VEGF gene functional variants with rheumatoid arthritis (RA). The population under study was composed of a total of 753 unrelated RA patients and 801 healthy controls. The VEGF -1154 G-->A and -634 G-->C polymorphism genotyping was performed by real-time polymerase chain reaction technology, using TaqMan 5' allelic discrimination assay. No evidence of association was observed between the -1154 G-->A and the -634 G-->C VEGF polymorphisms, or inferred VEGF haplotypes with RA susceptibility or clinical manifestations. Our results suggest that the analyzed VEGF promoter polymorphisms may not play a relevant role in RA pathogenesis in our population.
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