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  • Title: [Avoidance conditioning and morphometric characteristics of the sensorimotor cortex of rats exposed to social deprivation in early ontogeny].
    Author: Levshina IP, Pasikova NV, Shuĭkin NN.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 2005; 55(4):558-66. PubMed ID: 16217971.
    Abstract:
    Male Wistar rats were exposed to social deprivation in the period from the 22nd to 70th days of postnatal development. The characteristics of the learning of these rats at the age 110-120 days in the passive avoidance box and during training for active avoidance of electroshock were significant lower than those of control animals. Features of motor activities of the "isolants" in learning and testing, and in the "open field" may be related to their higher anxiety level. Morfometric studies of neurons and glial cells and neocortex thickness showed that significantly lower density of neural elements may be the result of the afferent sensory input limitation produced by the social deprivation.
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