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  • Title: Detecting single stranded DNA with a solid state nanopore.
    Author: Fologea D, Gershow M, Ledden B, McNabb DS, Golovchenko JA, Li J.
    Journal: Nano Lett; 2005 Oct; 5(10):1905-9. PubMed ID: 16218707.
    Abstract:
    Voltage biased solid-state nanopores are used to detect and characterize individual single stranded DNA molecules of fixed micrometer length by operating a nanopore detector at pH values greater than approximately 11.6. The distribution of observed molecular event durations and blockade currents shows that a significant fraction of the events obey a rule of constant event charge deficit (ecd) indicating that they correspond to molecules translocating through the nanopore in a distribution of folded and unfolded configurations. A surprisingly large component is unfolded. The result is an important milestone in developing solid-state nanopores for single molecule sequencing applications.
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