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  • Title: Mechanisms of regulation of erythropoiesis during experimental neuroses.
    Author: Skurikhin EG, Dygai AM, Provalova NV, Minakova MY, Suslov NI.
    Journal: Bull Exp Biol Med; 2005 May; 139(5):543-9. PubMed ID: 16224545.
    Abstract:
    We studied the mechanisms of erythropoiesis regulation in a conflict situation and during paradoxical sleep deprivation. Plastic reconstruction of the erythroid hemopoietic stem during experimental neuroses is regulated by a complex multicomponent and multilevel system. This system consists of central adrenergic structures, sympathetic part of the autonomic nervous system, and alpha- and beta-adrenoceptors on erythroid precursors and cells of the hemopoietic microenvironment. Erythroid cells receive instructive information from the central nervous system via adrenoceptors on cells of the hemopoiesis-inducing microenvironment and erythroid precursors. Hyperplasia (conflict situation) and suppression of erythropoiesis (paradoxical sleep deprivation) are associated with specificity of central adrenergic regulatory mechanisms.
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