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  • Title: Role of Thy 1,2+ cells in the regulation of hemopoiesis during experimental neuroses.
    Author: Skurikhin EG, Pershina OV, Suslov NI, Dygai AM, Gol'dberg ED.
    Journal: Bull Exp Biol Med; 2005 Jun; 139(6):643-6. PubMed ID: 16224569.
    Abstract:
    We studied the direct and stromal cell-mediated effects of bone marrow Thy 1,2+ cells on the growth of granulocyte-macrophage and erythroid colonies from the bone marrow of CBA/CaLac mice with experimental neuroses (conflict situation and paradoxical sleep deprivation). Proliferation and differentiation of hemopoietic precursors during neuroses are controlled by regulatory T cells. In conflict situation Thy 1,2+ cells stimulate the growth of hemopoietic precursors, which is associated with their direct effect and interaction with adherent cells of the hemopoiesis-inducing microenvironment. The interaction of Thy 1,2+ cells with adherent bone marrow cells during paradoxical sleep deprivation stimulates the formation of only granulocyte-macrophage colonies.
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