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  • Title: [Rofecoxib-related cutaneous vasculitis].
    Author: Defuentes G, Lecoules S, Coutant G, Algayres JP.
    Journal: Presse Med; 2005 Aug 27; 34(14):1007-8. PubMed ID: 16225254.
    Abstract:
    INTRODUCTION: Drugs are at the origin of around 10% of the cases of vasculitis involving the small vessels. Recent cases report vasculitis related to the administration of nonsteroidal antiinflammatory selective inhibitors of cyclo-oxygenase 2. CASE: Vasculitis associated with ketoprofen appeared in a 76 year-old man: the symptoms disappeared when treatment stopped. A few weeks later, during treatment with rofecoxib, a relapse appeared, including purpura. The diagnosis of rofecoxib-induced cutaneous vasculitis was confirmed by regression of all symptoms when treatment stopped. DISCUSSION: Coxibs, like other nonsteroidal antiinflammatory drugs, may cause vasculitis, at an as-yet undetermined frequency.
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