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  • Title: Cognitive competence at the onset of West syndrome: correlation with EEG patterns and visual function.
    Author: Randò T, Baranello G, Ricci D, Guzzetta A, Tinelli F, Biagioni E, La Torre G, Epifanio R, Signorini S, Fazzi E, Mercuri E, Cioni G, Guzzetta F.
    Journal: Dev Med Child Neurol; 2005 Nov; 47(11):760-5. PubMed ID: 16225740.
    Abstract:
    The aim of this study was to evaluate cognitive development at the onset of West syndrome (WS) with regard to electroencephalogram (EEG) patterns and visual function. Twenty-five patients (14 males, 11 females) at the onset of spasms (T0) in WS and 2 months later (T1) underwent a full clinical evaluation, including neuroimaging, cognitive assessment, video-EEG, and visual function. Mean age of the patients at spasm onset was 5.9 months (SD 2.5; range 2 to 13mo). Cognitive development, assessed with Griffiths Mental Development Scales (GMDS), was generally impaired at T0 and was significantly related to visual function (p<0.001) at both T0 and T1. In general, there was a specific major impairment in the eye-hand coordination scale of the GMDS which tended to disappear after 2 months in less severe cases. At the onset of spasms, sleep EEG organization seemed to be better related to cognitive abilities than awake hypsarrhythmia. These results support a close link between visual function and cognitive competence in WS and provide additional information to improve the understanding of possible mechanisms underlying cognitive impairment.
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