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  • Title: Dual modes of RNA-silencing suppression by Flock House virus protein B2.
    Author: Chao JA, Lee JH, Chapados BR, Debler EW, Schneemann A, Williamson JR.
    Journal: Nat Struct Mol Biol; 2005 Nov; 12(11):952-7. PubMed ID: 16228003.
    Abstract:
    As a counter-defense against antiviral RNA silencing during infection, the insect Flock House virus (FHV) expresses the silencing suppressor protein B2. Biochemical experiments show that B2 binds to double-stranded RNA (dsRNA) without regard to length and inhibits cleavage of dsRNA by Dicer in vitro. A cocrystal structure reveals that a B2 dimer forms a four-helix bundle that binds to one face of an A-form RNA duplex independently of sequence. These results suggest that B2 blocks both cleavage of the FHV genome by Dicer and incorporation of FHV small interfering RNAs into the RNA-induced silencing complex.
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