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  • Title: Larvicidal activity of Cybistax antisyphilitica against Aedes aegypti larvae.
    Author: Rodrigues AM, de Paula JE, Roblot F, Fournet A, Espíndola LS.
    Journal: Fitoterapia; 2005 Dec; 76(7-8):755-7. PubMed ID: 16229968.
    Abstract:
    The larvicidal activity against Aedes aegypti larvae of a stem wood hexane extract of Cybistax antisyphilitica was evaluated. Bioassay-guided fractionation of the crude extract, monitored by larvicidal assay, led to the isolation of a natural quinone identified as 2-hydroxy-3-(3-methyl-2-butenyl)-1.4-naphthoquinone (lapachol). This compound was quite potent against A. aegypti larvae (LC50 26.3 microg/ml).
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