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  • Title: [Recurrent vascular access trombosis associated with the prothrombin mutation G20210A in a adult patient in haemodialysis].
    Author: Quintana LF, Coll E, Monteagudo I, Collado S, López-Pedret J, Cases A.
    Journal: Nefrologia; 2005; 25(4):442-4. PubMed ID: 16231514.
    Abstract:
    Vascular access-related complications are a frequent cause of morbidity in haemodialysis patients and generate high costs. We present the case of an adult patient with end-stage renal disease and recurrent vascular access thrombosis associated with the prothrombin mutation G20210A and renal graft intolerance. The clinical expression of this heterozygous gene mutation may have been favoured by inflammatory state, frequent in dialysis patients. In this patient, the inflammatory response associated with the renal graft intolerance would have favored the development of recurrent vascular access thrombosis in a adult heterozygous for prothrombin mutation G20210A. In the case of early dysfunction of haemodialysis vascular access and after ruling out technical problems, it is convenient to carry out a screening for thrombophilia.
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