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  • Title: [Study of biocompatibility of polybutylcyanoacrylate nanoparticles].
    Author: Yang XX, Chen JH, Guo D.
    Journal: Di Yi Jun Yi Da Xue Xue Bao; 2005 Oct; 25(10):1261-3. PubMed ID: 16234103.
    Abstract:
    OBJECTIVE: To evaluate the biocompatibility of polybutylcyanoacrylate nanoparticles (PBCA-NP) manufactured by emulsion polymerization technique. METHODS: MTT assay was performed for evaluation of the cytotoxicity of PBCA-NP (e.g. cell proliferation and hemolytic test) experiments of long-term subcutaneous implantation and implantation in the muscular tissues of PBCA-NP was conducted in rabbits to observe the inflammatory reactions due to the implantation. RESULTS: No obvious cytotoxicity or hemolytic reactions were observed (with the hemolytic rate at different concentrations of PBCA-NP(5%). Three months after PBCA-NP implantation, obvious lymphocyte infiltration was not observed in the tissues around the implants which underwent gradual degradation. CONCLUSION: PBCA-NP possesses good biocompatibility.
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