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  • Title: [Diagnostic value of combined detection of TPS, CA153 and CEA in breast cancer].
    Author: Zheng H, Luo RC.
    Journal: Di Yi Jun Yi Da Xue Xue Bao; 2005 Oct; 25(10):1293-4, 1298. PubMed ID: 16234113.
    Abstract:
    OBJECTIVE: To study the diagnostic value of combined detection of the 3 tumor markers, namely tissue polypeptide specific antigen (TPS), cancer antigen 153 (CA153), and carcino embryonic antigen (CEA), in patients with breast cancer. METHODS: The serum levels of TPS, CA153 and CEA were determined by enzyme-linked immumosorbent assay in 90 patients with breast cancer and 30 healthy adults. RESULTS: The serum levels of 3 tumor markers in breast cancer patients were significantly higher than those in the control group (P<0.01). The sensitivity of TPS to breast cancer was 87.7% with specificity of 90.0%. The sensitivity and specificity of CA153 to breast cancer was 55.6% and 93.3%, and those of CEA was 45.8% and 96.7%, respectively. The sensitivity of the 3 tumor markers in combination was 100% in breast cancer diagnosis. CONCLUSION: TPS, CA153 and CEA have diagnostic value in breast cancer and possess obvious complementarity, and their combined detection can significantly improve the sensitivity of breast cancer diagnosis.
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