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  • Title: A double-blind study of ibuprofen versus placebo in the treatment of acute migraine attacks.
    Author: Kloster R, Nestvold K, Vilming ST.
    Journal: Cephalalgia; 1992 Jun; 12(3):169-71; discussion 128. PubMed ID: 1623513.
    Abstract:
    The efficacy of ibuprofen, a non-steroidal anti-inflammatory drug, was assessed in the acute treatment of migraine. Twenty-five patients completed a double-blind placebo-controlled multicrossover trial. The initial dose of ibuprofen was 1200 mg. Six migraine attacks were randomly treated in each patient, three with ibuprofen and three with placebo. The results indicated a statistically significant reduction in the duration of the migraine attacks and also a statistically significant reduction in the severity of headache and nausea in the ibuprofen-treated attacks. The use of additional medication was significantly reduced in the ibuprofen-treated attacks (25.6% vs 57.5%). No serious side effects were reported. Ibuprofen is valuable in the treatment of acute migraine attacks.
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