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  • Title: [Expression of corticotropin-releasing hormone and its receptor type-1 in the placental cotyledon vessels].
    Author: Wang XD, Yu HY, Yao Q, Liu SY.
    Journal: Sichuan Da Xue Xue Bao Yi Xue Ban; 2005 Sep; 36(5):634-6. PubMed ID: 16235524.
    Abstract:
    OBJECTIVE: To study the expression of corticotropin-releasing hormone(CRH) and its receptor type-1 in the placental cotyledon vessels at term. METHODS: IHC-SP staining and ISH methods were used to investigate the expression patterns of CRH and its receptor CRH-R1 in the placental cotyledon vessels at term from women who had undergone uncomplicated pregnancies. Placental tissues were collected after cesarian section before threatened labor. RESULTS: This study revealed for the first time that endothelial cells and even smooth muscle cells of the cotyledon vessel expressed CRH messenger ribonucleic acid and peptide as well as the CRH-R1. CONCLUSION: The novel findings disclosed that the CRH derived from endothelial cells and even smooth muscle cells of the cotyledon vessel may represent the main source of CRH levels in fetal plasma, thus indicating the capability of mobilizing the compensation mechanism for adapting to the acute stress.
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