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  • Title: Quencher-free, end-stacking oligonucleotides for probing single-base mismatches in DNA.
    Author: Seo YJ, Ryu JH, Kim BH.
    Journal: Org Lett; 2005 Oct 27; 7(22):4931-3. PubMed ID: 16235925.
    Abstract:
    [reaction: see text] Fluorescence can be quenched through PET from the fluorophore to neighboring C, T, and G bases, but not to the A moiety. The hairpin stem stability arising from pi-stacking and the PET between the pyrene-labeled 2'-deoxynucleotide units and their neighboring bases are the two main factors that affect the operation of these novel fluorescent oligonucleotides.
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