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  • Title: [Laboratory diagnosis of antiphospholipid syndrome].
    Author: Darnige L.
    Journal: Rev Med Interne; 2006 Apr; 27(4):296-301. PubMed ID: 16236386.
    Abstract:
    PURPOSE: The antiphospholipid syndrome is a bioclinical entity defined by the occurrence of thromboses, and/or obstetrical complications in the persistent presence of antiphospholipid antibodies, i.e. lupus anticoagulant and/or anticardiolipin antibodies. This review focuses on the methods for antiphospholipid antibodies detection and their clinical usefulness. CURRENT KNOWLEDGE AND KEY POINTS: Lupus anticoagulant is the strongest risk factor for thrombosis in antiphospholipid syndrome. Twenty years after its description, anticardiolipin ELISA, despite a still improvable standardization and its lack of specificity, is still required for sensitive diagnosis of antiphospholipid syndrome. FUTURE PROSPECTS AND PROJECTS: A better knowledge of the beta-2-glycoprotein-I role in the pathophysiology of antiphospholipid syndrome might lead to the development of new markers of thrombotic risk.
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