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  • Title: The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs.
    Author: Suh YG, Kim SN, Shin DY, Hyun SS, Lee DS, Min KH, Han SM, Li F, Choi EC, Choi SH.
    Journal: Bioorg Med Chem Lett; 2006 Jan 01; 16(1):142-5. PubMed ID: 16236511.
    Abstract:
    For the systematic SAR study on mansonone F, a series of C6 and C9 analogs of mansonone F have been synthesized and their anti-MRSA activities were evaluated. Most of the analogs exhibited good or excellent anti-MRSA activities. In particular, the 6-n-butylmansonone F showed fourfold higher antibacterial activities compared to that of vancomycin.
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