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  • Title: Pathogenesis of hypertrophic osteoarthropathy.
    Author: Martinez-Lavin M.
    Journal: Clin Exp Rheumatol; 1992; 10 Suppl 7():49-50. PubMed ID: 1623674.
    Abstract:
    The systematic study of patients with cyanotic heart diseases has led to a better understanding of the pathogenesis of hypertrophic osteoarthropathy (HOA). Current evidence suggests that in cases of right-to-left shunts of blood, HOA develops as a result of faulty pulmonary clearance of macrothrombocytes. There are theoretical grounds to suggest that a platelet-derived growth factor is also responsible for the acropachy associated with other types of internal illnesses.
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